ABSTRACT
<p><b>OBJECTIVE</b>To explore risk factors of injection-related sharp injury and to provide safety injection guidance to healthcare takers.</p><p><b>METHODS</b>A cross-sectional survey and 1:1 case-control study was used to study the epidemiological features and risk factors of sharp injuries among 3010 clinical nurses and nurse students from 13 hospitals in Guangzhou. Logistic multiple factor analysis was used.</p><p><b>RESULTS</b>Eighty-seven point five percent of nurses have suffered injuries at last once time. During the past month, 37.6% of the nurses have suffered injuries at least once time. The frequency of the injuries was 0.84 per person month. Through multiple logistic regression analysis, data showed that the risk factors leading to the sharp injuries in orders were: contacting the needle more frequently, subjectively thinking that the sharp injuries as unavoidable, the atmosphere in the nursing unit was not harmonious enough, recapping habit, carelessness at work, too many patients that not cooperating, breaking the ampule off without using carbasus, crowded and noisy working place, lack of acknowledge on prevention, lack of the awareness on how to avoiding the accident, having an initiative and creative personality etc.</p><p><b>CONCLUSION</b>The results provided a foundation for the department of infection control in the hospital and sanitary administration department to constitute safety injection policies.</p>